Sesame Care is a healthcare marketplace connecting patients with doctors for affordable, transparent-priced telehealth and in-person visits across many specialties.
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Complete 2026 Comparison for Weight Loss
TrimRx is our overall pick for weight loss, based on our rating and feature coverage.
Sesame Care is a healthcare marketplace connecting patients with doctors for affordable, transparent-priced telehealth and in-person visits across many specialties.
TrimRx is a telehealth weight loss platform offering compounded GLP-1 medications - semaglutide from $149/month and tirzepatide from $249/month - with licensed physician oversight, sourcing through licensed 503A compounding pharmacies, and a money-back guarantee.
| Feature | ||
|---|---|---|
| Rating | 9.1/10 | 9.4/10 |
| Founded | 2019 | 2020 |
| Free Consultation | No | Yes |
| Free Shipping | No | Yes |
| Accepts Insurance | No | No |
| HSA/FSA Accepted | Yes | Yes |
| Mobile App | Yes | No |
| Consultation Type | Video, In-person, Messaging | Async (text/questionnaire) |
| Shipping Time | Varies (prescriptions sent to pharmacy) | 3-5 business days |
| Treatment | ||
|---|---|---|
| Weight Loss | N/A | $179/month$179-$249/month |
The better choice depends on your specific needs and priorities. Sesame Care carries a 9.2/10 rating in our provider database and is listed as a fit for cash-pay patients without insurance. TrimRx carries a 9.2/10 rating in our provider database and is listed as a fit for patients wanting the lowest monthly glp-1 cost. Those scores are our own editorial ratings, not third-party review averages. Sesame Care was founded in 2019 in New York, NY, while TrimRx was founded in 2020 in United States. Both are US telehealth platforms that connect you with licensed providers, and which one suits you is a question for that provider.
Pricing varies by treatment category. Sesame Care pricing varies. TrimRx starts at $179/month (range: $179-$249/month). These are the rates last recorded in our provider database, so confirm the current price at checkout before you enroll. TrimRx lists free consultations. TrimRx lists free shipping. Sesame Care and TrimRx list HSA and FSA payment options, though whether a given charge is eligible depends on your plan and on IRS rules for that expense.
Sesame Care does not list health insurance as accepted, and operates on a cash-pay model with published pricing. TrimRx does not list insurance as accepted. Sesame Care and TrimRx list HSA and FSA payment options; eligibility for any specific charge depends on your plan and IRS rules, so check with your plan administrator first. Coverage and pricing change, so confirm both with the platform and your insurer before you enroll.
Both are established US telehealth platforms. Sesame Care was founded in 2019 and is headquartered in New York, NY. TrimRx was founded in 2020 in United States. Both state that they work with US-licensed providers and licensed pharmacies and that they operate under HIPAA. We do not independently audit provider credentials or pharmacy licensing, so if you want that confirmed, you can look up an individual prescriber through your state medical board and a pharmacy through your state board of pharmacy.
Sesame Care offers video and in-person and messaging consultations. TrimRx provides async (text/questionnaire) consultations (free). On both, you complete a health questionnaire online that a licensed provider reviews. Video consultations are available if you prefer to speak with a provider face to face. Turnaround times vary by platform, by state, and by how busy the provider network is, and you can message your provider with follow-up questions through the platform.
Sesame Care lists shipping within Varies (prescriptions sent to pharmacy). TrimRx lists shipping within 3-5 business days with free standard shipping. Both describe discreet packaging, and medications ship from licensed pharmacies rather than from the platform itself. Actual delivery time depends on your state, the pharmacy, and whether your prescription needs follow-up. You can track your shipment through the provider's mobile app or website.
Sesame Care has a mobile app for iOS and Android that you can use to manage prescriptions, message providers, track orders, and see your health information. TrimRx provides a mobile-optimized website for on-the-go access.
Sesame Care offers both subscription and one-time purchase options and lists cancellation at any time without a fee. TrimRx also uses a subscription model and lists no cancellation penalty. Cancellation terms are set by each platform and can change, so read the current terms before you enroll. As a general rule you need to cancel before your next billing date to avoid the following period's charge, and anything already shipped is still yours.
Sesame Care lists GLP-1 Consultations, Weight Management starting at prices that vary. TrimRx lists Compounded Semaglutide, Compounded Tirzepatide starting at $179/month. Wegovy (semaglutide) and Zepbound (tirzepatide) are the brand-name injectables FDA-approved for weight management. Where a program dispenses compounded semaglutide or tirzepatide instead, that is a pharmacy-prepared drug rather than the approved finished product. Compounded drugs are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness, or quality. Programs typically bundle medication, provider consultations, and check-ins, and they differ mainly on price, on which medications they carry, and on how much support is included. Whether any of this is appropriate for you is a question for a licensed provider.
Side effects come from the medication, not from the platform, so this is mostly a question about the drug you end up on rather than about Sesame Care versus TrimRx. Reported effects vary by treatment: ED medications may cause headache, flushing, or nasal congestion; finasteride carries labeled sexual side effects that some men report persisting after they stop; GLP-1 medications commonly cause nausea, vomiting, and other gastrointestinal effects, especially when the dose goes up; SSRIs may cause drowsiness, nausea, or changes in appetite and sexual function. This is not the full list for any of them. Both platforms have licensed providers review your medical history and screen for contraindications, and you should read the medication guide and raise anything you notice with your provider.
Choose Sesame Care if you prioritize: cash-pay patients without insurance, those wanting transparent pricing. Choose TrimRx if you prioritize: patients wanting the lowest monthly glp-1 cost, those who want a money-back guarantee. Sesame Care stands out for: Healthcare marketplace model. TrimRx is known for: Money-back guarantee if you do not lose weight. Both are established telehealth platforms, so your choice mostly comes down to price, which treatments each one carries, and how you prefer to handle visits and refills.
The process is similar on both. For Sesame Care: visit their website, select your treatment category, and complete a health questionnaire that a licensed provider reviews. For TrimRx: follow the same kind of flow on their platform. Both ask for your medical history, current medications, and answers to health screening questions, and being straight with those answers is what lets the provider catch an interaction. If you are approved, the prescription goes to a licensed pharmacy and ships to you (often with free shipping). How long the whole thing takes depends on the platform, your state, and the pharmacy.
Sesame Care carries a 9.2/10 rating in our provider database, and TrimRx carries a 9.2/10 rating in our provider database. Those are ManyTreatments editorial scores on a 10-point scale, not averages pulled from third-party review sites, and you can read how we build them on our how-we-rate page. What we weigh: Sesame Care scores well on transparent pricing upfront, with does not accept insurance as the trade-off. For TrimRx it is lowest price in market at $149/month for semaglutide, against weight loss only - no multi-condition coverage. If you want customer sentiment as well, check current listings on the review platforms directly, since those move.
Medical Disclaimer: The information on this page is for educational purposes only and is not medical advice. Always consult with a licensed healthcare provider before starting any treatment. Read our full medical disclaimer.
Regulatory noticeRegulatory note (verified August 22, 2026): On February 20, 2026 the FDA issued MEDVi, LLC a warning letter (MARCS-CMS 721455) citing misbranding under sections 502(a) and 502(bb) of the FD&C Act. Reviewing medvi.io in December 2025, the FDA said labels bearing "MEDVi" implied MEDVi compounds the drugs when it does not, and that "Same active ingredient as Wegovy and Ozempic" and "Same active ingredient as Mounjaro and Zepbound" implied an FDA approval compounded drugs do not have. We found no close-out letter, so the matter appears open. MEDVi states medvi.io is affiliate-operated rather than company-operated; we could not verify that, and the letter is addressed to MEDVi, LLC. Read the FDA letter